Journal
JOURNAL OF INVESTIGATIVE AND CLINICAL DENTISTRY
Volume 5, Issue 2, Pages 81-90Publisher
WILEY
DOI: 10.1111/jicd.12089
Keywords
chronic periodontitis; periodontal disease; periodontal ligament stem cells; regeneration; tissue engineering
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Chronic periodontitis is a serious infectious and inflammatory oral disease of humans worldwide. Conventional treatment modalities are effective for controlling periodontal disease. However, the regeneration of damaged periodontal tissues remains a major challenge in clinical practice due to the complex structure of the periodontium. Stem cell-based regenerative approaches combined with the usage of emerging biomaterials are entering a new era in periodontal regeneration. The present review updates the current knowledge of periodontal ligament stem cell-based approaches for periodontal regeneration, and elaborates on the potentials for clinical application.
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