Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 96, Issue 6, Pages 1021-1042Publisher
WILEY
DOI: 10.1002/jnr.24224
Keywords
EAE; ethidium bromide; glial cells; lysolecithin toxin and virus-induced demyelination; multiple sclerosis
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Funding
- Ministry of Education, Science and Technological Development, Republic of Serbia [III 41014]
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Multiple sclerosis (MS) is a chronic, progressive disorder of the central nervous system (CNS) that affects more than two million people worldwide. Several animal models resemble MS pathology; the most employed are experimental autoimmune encephalomyelitis (EAE) and toxin- and/or virus-induced demyelination. In this review we will summarize our knowledge on the utility of different animal models in MS research. Although animal models cannot replicate the complexity and heterogeneity of the MS pathology, they have proved to be useful for the development of several drugs approved for treatment of MS patients. This review focuses on EAE because it represents both clinical and pathological features of MS. During the past decades, EAE has been effective in illuminating various pathological processes that occur during MS, including inflammation, CNS penetration, demyelination, axonopathy, and neuron loss mediated by immune cells.
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