Journal
JOURNAL OF NEUROLOGY
Volume 266, Issue 1, Pages 1-26Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-018-8892-x
Keywords
Lewy body dementia; Neuroimaging; MRI; Molecular imaging; PET; SPECT
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Funding
- MRC [1856197] Funding Source: UKRI
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Lewy body dementia (DLB) is a common form of cognitive impairment, accounting for 30% of dementia cases in ages over 65years. Early diagnosis of DLB has been challenging; particularly in the context of differentiation with Parkinson's disease dementia and other forms of dementias, such as Alzheimer's disease and rapidly progressive dementias. Current practice involves the use of [I-123]FP-CIT-SPECT, [F-18]FDG PET and [I-123]MIBG molecular imaging to support diagnostic procedures. Structural imaging techniques have an essential role for excluding structural causes, which could lead to a DLB-like phenotype, as well as aiding differential diagnosis through illustrating disease-specific patterns of atrophy. Novel PET molecular imaging modalities, such as amyloid and tau imaging, may provide further insights into DLB pathophysiology and may aid in early diagnosis. A multimodal approach, through combining various established techniques and possibly using novel radioligands, might further aid towards an in-depth understanding of this highly disabling disease. In this review, we will provide an overview of neuroimaging applications in patients with DLB.
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