Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 323, Issue -, Pages 43-48Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.07.008
Keywords
Multiple sclerosis; Microvesicles; Fingolimod; P2X7 receptor; Acid sphingomyelinase; IL-1 beta
Categories
Ask authors/readers for more resources
Recently, microvesicles (MVs) were considered as important mediators of intercellular communication, especially in pathological conditions as Multiple Sclerosis (MS). In myeloid cells, MV shedding is induced by the receptor P2X7 with the involvement of acid sphingomyelinase (A-SMase) and release of the IL-1 beta. In this study we evaluate how Fingolimod affects MVs production by the monocytes, as well as P2X7R, IL-1 beta expression and A-SMase activity. Treatment decreased MVs production and IL-1 beta expression. This effect was associated with the inhibition of A-SMase activity in BzATP-stimulated monocytes from MS patients. These evidences suggest monocyte MVs as a possible disease and drug-efficacy biomarkers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available