Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 314, Issue -, Pages 101-105Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2017.12.001
Keywords
Exercise; MS; Kynurenine; Tryptophan; 5HT
Categories
Funding
- Swiss MS Society
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Disturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobic exercise and training on Tryptophan metabolism in 57 inpatients with relapsing remitting ((ARMS) n = 33) and secondary progressive ((SPMS) n = 24) MS. Serotonin increased after training, whereas the kynurenine pathway was only activated in persons with ARMS. Further research is warranted to investigate whether these changes are associated with clinical measures (e.g. depressions and immune function).
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