Journal
JOURNAL OF NEUROENDOCRINOLOGY
Volume 30, Issue 2, Pages -Publisher
WILEY
DOI: 10.1111/jne.12547
Keywords
17-oestradiol; androgens; autism spectrum conditions; neurodegenerative disease; neurodevelopmental disorders; oestrogens; psychiatric; schizophrenia; stem cells; synapse; testosterone
Categories
Funding
- Medical Research Council [MR/L021064/1]
- Brain and Behavior Research Foundation
- European Autism Interventions (EU-AIMS)
- Wellcome Trust [097819]
- King's Health Partners Research and Development Challenge Fund
- King's Health Partners by Guy's and St Thomas' Charity
- Innovative Medicines Initiative Joint Undertaking [115300, FP7/20072013]
- European Union [115300]
- Mortimer D Sackler Foundation
- Autism Research Trust
- Chinese University of Hong Kong
- Jawaharlal Nehru Memorial Trust
- Templeton World Charitable Foundation
- National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care East of England at Cambridgeshire and Peterborough NHS Foundation Trust
- Alzheimers Research UK [ARUK-PhD2016-4] Funding Source: researchfish
- Medical Research Council [MC_UP_1201/9, MR/L021064/1, G0600977, MR/N026063/1] Funding Source: researchfish
- MRC [MR/N026063/1, G0600977, MC_UP_1201/9, MR/L021064/1] Funding Source: UKRI
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Steroids have an important role in growth, development, sexual differentiation and reproduction. All four classes of steroids, androgens, oestrogens, progestogens and glucocorticoids, have varying effects on the brain. Androgens and oestrogens are involved in the sexual differentiation of the brain, and also influence cognition. Progestogens such as progesterone and its metabolites have been shown to be involved in neuroprotection, although their protective effects are timing-dependent. Glucocorticoids are linked with stress and memory performance, also in a dose- and time-dependent manner. Importantly, dysfunction in steroid function has been implicated in the pathogenesis of disease. Moreover, regulating steroid-signalling has been suggested as potential therapeutic avenue for the treatment of a number of neurodevelopmental, psychiatric and neurodegenerative disorders. Therefore, clarifying the role of steroids in typical and atypical brain function is essential for understanding typical brain functions, as well as determining their potential use for pharmacological intervention in the atypical brain. However, the majority of studies have thus far have been conducted using animal models, with limited work using native human tissue or cells. Here, we review the effect of steroids in the typical and atypical brain, focusing on the cellular, molecular functions of these molecules determined from animal models, and the therapeutic potential as highlighted by human studies. We further discuss the promise of human-induced pluripotent stem cells, including advantages of using three-dimensional neuronal cultures (organoids) in high-throughput screens, in accelerating our understanding of the role of steroids in the typical brain, and also with respect to their therapeutic value in the understanding and treatment of the atypical brain.
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