Journal
JOURNAL OF NEUROCHEMISTRY
Volume 147, Issue 6, Pages 715-729Publisher
WILEY
DOI: 10.1111/jnc.14455
Keywords
cortex; food reward; lateral hypothalamus; obesity
Categories
Funding
- Australian NHMRC [1140197, 1084344]
- Australian Government Research Training Program Scholarship
- National Health and Medical Research Council of Australia [1084344, 1140197] Funding Source: NHMRC
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Emerging evidence from human imaging studies suggests that obese individuals have altered connectivity between the hypothalamus, the key brain region controlling energy homeostasis, and cortical regions involved in decision-making and reward processing. Historically, animal studies have demonstrated that the lateral hypothalamus is the key hypothalamic region involved in feeding and reward. The lateral hypothalamus is a heterogeneous structure comprised of several distinct types of neurons which are scattered throughout. In addition, the lateral hypothalamus receives inputs from a number of cortical brain regions suggesting that it is uniquely positioned to be a key integrator of cortical information and metabolic feedback. In this review, we summarize how human brain imaging can inform detailed animal studies to investigate neural pathways connecting cortical regions and the hypothalamus. Here, we discuss key cortical brain regions that are reciprocally connected to the lateral hypothalamus and are implicated in decision-making processes surrounding food.
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