Journal
JOURNAL OF NEURO-ONCOLOGY
Volume 139, Issue 3, Pages 633-642Publisher
SPRINGER
DOI: 10.1007/s11060-018-2908-3
Keywords
Grade II; III gliomas; Texture analysis; IDH; 1p/19q; Magnetic resonance imaging
Categories
Funding
- National Institutes of Health [R01NS065838, UL1TR000100, KL2TR00144]
- American Cancer Society [ACS-IRG 70-002, RSG-15-229-01-CCE]
Ask authors/readers for more resources
BackgroundMolecular markers of WHO grade II/III glioma are known to have important prognostic and predictive implications and may be associated with unique imaging phenotypes. The purpose of this study is to determine whether three clinically relevant molecular markers identified in gliomasIDH, 1p/19q, and MGMT statusshow distinct quantitative MRI characteristics on FLAIR imaging.MethodsSixty-one patients with grade II/III gliomas who had molecular data and MRI available prior to radiation were included. Quantitative MRI features were extracted that measured tissue heterogeneity (homogeneity and pixel correlation) and FLAIR border distinctiveness (edge contrast; EC). T-tests were conducted to determine whether patients with different genotypes differ across the features. Logistic regression with LASSO regularization was used to determine the optimal combination of MRI and clinical features for predicting molecular subtypes.ResultsPatients with IDH wildtype tumors showed greater signal heterogeneity (p=0.001) and lower EC (p=0.008) within the FLAIR region compared to IDH mutant tumors. Among patients with IDH mutant tumors, 1p/19q co-deleted tumors had greater signal heterogeneity (p=0.002) and lower EC (p=0.005) compared to 1p/19q intact tumors. MGMT methylated tumors showed lower EC (p=0.03) compared to the unmethylated group. The combination of FLAIR border distinctness, heterogeneity, and pixel correlation optimally classified tumors by IDH status.ConclusionQuantitative imaging characteristics of FLAIR heterogeneity and border pattern in grade II/III gliomas may provide unique information for determining molecular status at time of initial diagnostic imaging, which may then guide subsequent surgical and medical management.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available