Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 125, Issue 8, Pages 1195-1202Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-018-1865-5
Keywords
Parkinson's disease; Dyskinesia; Serotonin; Serotonin autoreceptors; L-DOPA
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Funding
- Michael J Fox Foundation
- Parkinson's Disease Foundation
- Italian Ministry of Education, Universities and Research, Progetto di Ricerca di Interesse Nazionale (PRIN) [2010-AHHP5H]
- Swedish Research Council [04X-3824]
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During the last decade, the serotonergic system has emerged as a key player in the appearance of L-DOPA-induced dyskinesia in animal models of Parkinson's disease. Clinical investigations, based on imaging and postmortem analyses, suggest that the serotonin neurons are also involved in the etiology of this complication of long-term L-DOPA treatment in parkinsonian patients. These findings have stimulated efforts to develop new therapies using drugs targeting the malfunctioning serotonin neurons. In this review, we summarize the experimental and clinical data obtained so far and discuss the prospects for further development of this therapeutic strategy.
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