Journal
JOURNAL OF NATURAL MEDICINES
Volume 72, Issue 3, Pages 768-773Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s11418-018-1189-7
Keywords
Orchidaceae; Liparis bootanensis Griff.; Flavonol glycosides; Bootanensides; Antiinflammatory
Categories
Funding
- National Natural Science Foundation of China [81402803]
- project of Science and Technology Bureau of Chengdu [2015-HM01-00041-SF]
- US National Institutes of Health [R01 HL128647]
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Two new flavonol glycosides, bootanenside I and II (1 and 2), along with ten known compounds (3-12), were isolated from whole plant of Liparis bootanensis Griff. Their structures were elucidated on the basis of extensive spectroscopic analyses, including high-resolution electrospray-ionization mass spectrometry (HR-ESIMS) and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR). The cytotoxicity of the compounds was investigated against HCT116 human cancer cell line, revealing that none of them possessed considerable cytotoxic activity. Bioassays of the new metabolites showed that compounds 1 and 2 displayed moderate in vitro antiinflammatory activity by inhibiting expression of inducible nitric oxide synthase (iNOS) protein in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
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