Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 18, Issue 6, Pages 4428-4438Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2018.15235
Keywords
PCL Nanocapsules; Solid Lipid Nanoparticles; Semisolid Formulation; Hydrogel; Topical Anesthetics; Articaine
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Funding
- Sao Paulo Research Foundation (FAPESP) [2010/11097-7, 2010/18529-0]
- National Counsel of Technological and Scientific Development (CNPq)
- FUNDUNESP
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [10/18529-0] Funding Source: FAPESP
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This work describes the development of poly-epsilon-caprolactone nanocapsules (PCL-NC) and solid lipid nanoparticles (SLN) aiming delivery for articaine (ATC), in order to improve its chemical stability in semi-solid preparations looking forward their use for skin delivery. The nanoparticles were characterized by size, polydispersity index, and pH. Cellular viability was evaluated using the MTT test and the in vitro release kinetics was determined using a two-compartment model. The hydrogels with nanoparticle suspensions were characterized considering their rheological aspects and in vitro permeation across artificial membranes. Colloidal stability was satisfactory, since the formulations did not present major alterations during 120 days. High ATC encapsulation was achieved (78% for PCL-NC and 65% for SLN). The release profile of PCL-NC-ATC was slower, compared to the free molecule and SLN-ATC. MTT experiments showed the nanosystems were capable to increase cellular viability compared with free ATC. The hydrogels showed good consistency, homogeneity, and stability and presented pseudoplastic behavior with thixotropy, improving drug efficacy in clinical applications. The gel based on PCL-NC showed faster onset of activity and flux of 35.68 +/- 1.98 mu g/cm(2)/h, which then continued for up to 8 h. This study opens up prospects for employment of nanoparticulate systems for modified release of ATC.
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