Journal
JOURNAL OF NANOPARTICLE RESEARCH
Volume 20, Issue 6, Pages -Publisher
SPRINGER
DOI: 10.1007/s11051-018-4273-8
Keywords
Interendothelial transport; Nanomedicine; Nanoparticle; Solid tumors; Transendothelial transport; Nanoparticle accumulation in tumors
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Funding
- NCI NIH HHS [R01 CA194058] Funding Source: Medline
- NIBIB NIH HHS [R13 EB021826, R01 EB022040] Funding Source: Medline
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Two transport pathways (interendothelial and transendothelial routes) have long been proposed for entry of nanoparticles from the blood circulation into solid tumors. We examine and discuss available evidence supporting interendothelial and transendothelial transport processes and suggest new avenues for reevaluating these pathways. Understanding of integrative mechanisms controlling nanoparticle extravasation into tumors is important for improving engineering and performance of anti-cancer nanopharmaceuticals.
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