Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1154, Issue -, Pages 256-260Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2017.10.052
Keywords
Schiff base; Amino acid; Glycine; Phenylalanine; Antimicrobial; Complex
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Funding
- Selcuk University Research Foundation (SUBAP) (under projects FBE) [16201006]
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Zinc (II), copper (II), nickel (II), cobalt (II) and iron (III) complexes of Schiff bases (L-G, L-P) derived from 2-hydroxynaphthaldehyde with glycine and phenylalanine were reported and characterized by H-1 NMR, C-13 NMR, elemental analyses, melting point, FT-IR, magnetic susceptibility and thermal analyses (TGA). TGA data show that iron and cobalt include to the coordinated water and metal:ligand ratio is 1:2 while the complex stoichiometry for Ni (II), Cu (II) and Zn (II) complexes is 1:1. As expected, Ni (II) and Zn (II) complexes are diamagnetic; Cu (II), Co (II) and Fe (III) complexes are paramagnetic character due to a strong ligand of L-G and L-P. The L-G, L-P and their metal complexes were screened for their antimicrobial activities against five Gram-positive (Staphylococcus aureus, Methicillin resistant Staphylococcus aureus (MRSA), Bacillus cereus, Streptococcus mutans and Enterococcus faecalis) and three Gram-negative (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) and one fungi (Candida albicans) by using broth microdilution techniques. The activity data show that ligands and their metal complexes exhibited moderate to good activity against Gram-positive bacteria and fungi. (C) 2017 Elsevier B.V. All rights reserved.
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