Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1171, Issue -, Pages 631-638Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2018.06.050
Keywords
Trifluoromethylpyrazole; Urea; Fungicidal activity; Docking; Synthesis
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Funding
- Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University [2018GDGP0104]
- Zhejiang Provincial Natural Science Foundation of China [LY16C140007]
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Thirteen novel trifluoromethylpyrazole acyl urea derivatives were designed and synthesized. In vivo fungicidal activities of these compounds were tested against Fusarium oxysporum, Corynespora mazei, Botrytis cinerea and Pseudomonas syringae respectively, particularly compounds exhibited significant control effective at 100 mg/L More importantly, some compounds showed the good control effective at 10 mg/L Furthermore, docking was established to study the structure-activity relationship of the title compounds. It is possible that trifluoromethylpyrazole acyl urea derivatives, which possess good control effective against Fusarium oxysporum, Corynespora mazei and Botrytis cinerea, may become novel lead compounds for the development of fungicides with further structure modification. (C) 2018 Elsevier B.V. All rights reserved.
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