Carbamazepine cocrystals with several aromatic carboxylic acids in different stoichiometries: Structures and solid state characterization

A series of carbamazepine cocrystals with aromatic carboxylic acids have been prepared, including (CBZ)(1)(DBA)(1), (CBZ)(2)(DBA)(1)(CH3OH)(1) (DBA = 2,3-dihydroxy benzoic acid), (CBZ)(1)(NA)(1)(H2O)(1) (NA = 1-naphthoic acid) and (CBZ)(1)(AC)(1) (AC = anthracene-9-carboxylic acid). The synthons formed in CBZ cocrystals, e.g. amide center dot center dot center dot acid heterodimer, amide center dot center dot center dot amide homodimer, and amide center dot center dot center dot acid center dot center dot center dot H2O heterosynthon have been discussed and compared with synthons in reported CBZ cocrystals in CSD. The solid state properties of these cocrystals, such as transformation, solubility and their stabilities have been discussed in the article. (C) 2018 Elsevier B.V. All rights reserved.