Journal
EMERGING INFECTIOUS DISEASES
Volume 20, Issue 4, Pages 560-572Publisher
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2004.131769
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Funding
- Hong Kong Special Administrative Region Health
- Medical Research Fund
- Seed Funding for TRS, The University of Hong Kong
- Strategic Research Theme Fund, The University of Hong Kong
- Theme-based Research Scheme
- Research Grant Council Grant
- University Grant Council
- Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for the Hong Kong Special Administrative Region Department of Health
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In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested. In an analysis of 3 complete DcCoV UAE-HKU23 genomes, we identified the virus as a betacoronavirus in lineage A1. The DcCoV UAE-HKU23 genome has G+C contents; a general preference for G/C in the third position of codons; a cleavage site for spike protein; and a membrane protein of similar length to that of other betacoronavirus A1 members, to which DcCoV UAE-HKU23 is phylogenetically closely related. Along with this coronavirus, viruses of at least 8 other families have been found to infect camels. Because camels have a close association with humans, continuous surveillance should be conducted to understand the potential for virus emergence in camels and for virus transmission to humans.
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