Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1157, Issue -, Pages 312-321Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2017.12.080
Keywords
Coumarin; 1,2,3-Triazole; Cycloaddition; Antimicrobial; Antimycobacterial; Molecular docking
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Funding
- Council of Scientific and Industrial Research, New Delhi
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The present study demonstrated the synthesis of new series of coumarin-1,2,3-triazole hybrids under microwave irradiation method. Several dimers of coumarin based 1,2,3-triazole derivatives were synthesized and their antimycobacterial and antimicrobial activities were investigated. The antimycobacterial activity screening results revealed that compounds 6i and 6j were the most active against Mycobacterium tuberculosis H37Rv strain. The active compounds were further evaluated for cytotoxicity with HEK cell lines and exhibited less % of inhibition. The same synthetic hybrids were evaluated for their antimicrobial activity against various bacterial strains and fungal strains and compounds 6e, 6h, 6i and 6j were found to be the most promising antimicrobial potent molecules. Furthermore, the active compounds against Mycobacterium tuberculosis were evaluated for their molecular docking studies against pantothenate synthetase (PS) enzyme of MTB and the docking results are in well agreement with the antitubercular evaluation results. (C) 2017 Elsevier B.V. All rights reserved.
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