Journal
NATURE REVIEWS IMMUNOLOGY
Volume 14, Issue 4, Pages 271-280Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3642
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Funding
- US National Institutes of Health [U01AI082110, U19-AI089987, U19-AI08998, U19-AI057234]
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Individual elements that constitute the immune system have been characterized over the few past decades, mostly through reductionist approaches. The introduction of large-scale profiling platforms has more recently facilitated the assessment of these elements on a global scale. However, the analysis and the interpretation of such large-scale datasets remains a challenge and a barrier for the wider adoption of systems approaches in immunological and clinical studies. In this Innovation article, we describe an analytical strategy that relies on the a priori determination of co-dependent gene sets for a given biological system. Such modular transcriptional repertoires can in turn be used to simplify the analysis and the interpretation of large-scale datasets, and to design targeted immune fingerprinting assays and web applications that will further facilitate the dissemination of systems approaches in immunology.
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