Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 430, Issue 22, Pages 4557-4579Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2018.06.039
Keywords
protein exchange; bacterial flagellar motor; stator; type III secretion system; FRAP
Categories
Funding
- Engineering and Physical Sciences Research Council [EP/N509711/1, EP/M002187/1]
- Biotechnology and Biological Sciences Research Council [BB/N006070/1]
- BBSRC [BB/N006070/1, BB/H01991X/1] Funding Source: UKRI
- EPSRC [EP/M002454/1, EP/M002187/1] Funding Source: UKRI
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Over the past 50 years, protein complexes have been studied with techniques such as X-ray crystallography and electron microscopy, generating images which although detailed are static and homogeneous. More recently, limited application of in vivo fluorescence and other techniques has revealed that many complexes previously thought stable and compositionally uniform are dynamically variable, continually exchanging components with a freely circulating pool of spares. Here, we consider the purpose and prevalence of protein exchange, first reviewing the ongoing story of exchange in the bacterial flagella motor, before surveying reports of exchange in complexes across all domains of life, together highlighting great diversity in timescales and functions. Finally, we put this in the context of high-throughput proteomic studies which hint that exchange might be the norm, rather than an exception. (C) 2018 Elsevier Ltd. All rights reserved.
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