Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 430, Issue 2, Pages 207-216Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2017.10.003
Keywords
inflammasome; caspase-11; LPS; outer-membrane vesicles; gasdermin D
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Funding
- Charles Hood Child Health Research Award by Charles H. Hood Foundation
- National Institutes of Health [A1119015]
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Inflammasomes are cytosolic multi-molecular complexes that sense intracellular microbial danger signals and metabolic perturbations. Inflammasome activation leads to the activation of caspase-1 and the release of pro-inflammatory cytokines IL-1 beta and IL-18 accompanied by cell death. An inflammasome-based surveillance machinery for Gram-negative bacterial infections has been recently discovered. This noncanonical inflammasome relies on sensing the cytosolic presence of lipopolysaccharide of Gram-negative bacteria via inflammatory caspases such as caspase-4, -5, and -11. This review discusses the recent findings related to the mechanism of activation of the noncanonical inflammasome and, its biological functions. (C) 2017 Published by Elsevier Ltd.
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