Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 430, Issue 23, Pages 4754-4761Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2018.06.023
Keywords
phase separation; biopolymer condensates; viscoelastic properties; surface interface energy; mechanical potential
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Funding
- Canadian Institutes of Health Research [MOP-GMX-152556]
- Fonds Quebecois de al Recherche sur la nature er Les Technologies
- Human Frontiers Science Program grant [RGP0034/2017]
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The spontaneous nature of biopolymer phase separation in cells entails that the resulting condensates can be thermodynamic machines, which, in the process of condensing, can take on distinct forms themselves and deform neighboring cellular structures. We introduce here general notions of material and mechanical properties of protein condensates with an emphasis on how molecular arrangements and intermolecular interaction within condensates determine their ability to do work on their surroundings. We further propose functional implications of these concepts to cellular and subcellular morphology and biogenesis. (C) 2018 Elsevier Ltd. All rights reserved.
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