Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 430, Issue 23, Pages 4685-4701Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2018.05.003
Keywords
RNA; phase separation; membraneless organelle
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Funding
- NIH [GM111700, GM121410, AI007306]
- NATIONAL CANCER INSTITUTE [R01CA168872] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI033600, T32AI007306] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R35GM126901, R01GM111700] Funding Source: NIH RePORTER
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Phase transitions that alter the physical state of ribonucleoprotein particles contribute to the spacial and temporal organization of the densely packed intracellular environment. This allows cells to organize biologically coupled processes as well as respond to environmental stimuli. RNA plays a key role in phase separation events that modulate various aspects of RNA metabolism. Here, we review the role that RNA plays in ribonucleoprotein phase separations. (C) 2018 Elsevier Ltd. All rights reserved.
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