Journal
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Volume 28, Issue 4, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/1361-6439/aaa993
Keywords
microfluidics; cell culture; gaseous microenvironment
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Funding
- National Health Research Institutes (NHRI) in Taiwan under the Innovative Research Grant (IRG) [EX106-10523EI]
- Taiwan Ministry of Science and Technology [MOST 104-2221-E-001-015-MY3, 105-2221-E-001-002-MY2]
- Academia Sinica Career Development Award
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Gaseous microenvironments play important roles in various biological activities in vivo. However, it is challenging to precisely control gaseous microenvironments in vitro for cell culture due to the high diffusivity nature of gases. In recent years, microfluidics has paved the way for the development of new types of cell culture devices capable of manipulating cellular microenvironments, and provides a powerful tool for in vitro cell studies. This paper reviews recent developments of microfluidic cell culture devices for the control of gaseous microenvironments, and discusses the advantages and limitations of current devices. We conclude with suggestions for the future development of microfluidic cell culture devices for the control of gaseous microenvironments.
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