Journal
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
Volume 28, Issue 2, Pages 181-189Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
DOI: 10.4014/jmb.1707.07029
Keywords
Candida albicans; oxidative stress response; histone acetyltransferase
Categories
Funding
- National Research Foundation of Korea (NRF) - Korean Government (MSIP) [NRF-2015R1A4A1041105, NRF-2015R1D1A1A02061743]
- Global PhD Fellowship Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2014H1A2A1021300]
- National Research Foundation of Korea [2014H1A2A1021300] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Candida albicans is a major pathogenic fungus in humans, and meets at first the innate immune cells, such as macrophages, in its host. One important strategy of the host cell to kill C. albicans is to produce reactive oxygen species (ROS) by the macrophages. In response to ROS produced by the macrophages, C. albicans operates its defense mechanisms against them by expressing its oxidative stress response genes. Although there have been many research studies explaining the specific transcription factors and the expression of the oxidative stress genes in C. albicans, the regulation of the oxidative stress genes by chromatin structure is little known. Epigenetic regulation by the chromatin structure is very important for the regulation of eukaryotic gene expression, including the chromatin structure dynamics by histone modifications. Among various histone modifications, histone acetylation is reported for its direct relationship to the regulation of gene expression. Recent studies reported that histone acetyltransferases regulate genes to respond to the oxidative stress in C. albicans. In this review, we introduce all histone acetyltransferases that C. albicans contains and some papers that explain how histone acetyltransferases participate in the oxidative stress response in C. albicans.
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