Journal
GLYCOCONJUGATE JOURNAL
Volume 32, Issue 7, Pages 465-473Publisher
SPRINGER
DOI: 10.1007/s10719-015-9584-8
Keywords
Functional Glycomics; Glycans; Glycan microarray; Shotgun glycomics; Natural glycans
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Funding
- NIH [P41GM103694]
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This review discusses the challenges facing research in 'functional glycomics' and the novel technologies that are being developed to advance the field. The structural complexity of glycans and glycoconjugates makes studies of both their structures and recognition difficult. However, these intricate structures can be captured from their natural sources, isolated and fluorescently-tagged for detailed structural analysis and for presentation on glycan microarrays for functional recognition by glycan-binding proteins. These advances in glycan preparation and manipulation enable the streamlining of functional glycomics studies and will help to propel the field forward in studying natural, biologically relevant glycans.
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