Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 61, Issue 5, Pages 2111-2117Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.7b01824
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Funding
- Wellcome Trust Investigator award [099266/Z/12/Z]
- Wellcome Trust Pathfinder award [200983/Z/16/Z]
- Wellcome Trust [200983/Z/16/Z, 099266/Z/12/Z] Funding Source: Wellcome Trust
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The aryloxy triester phosphoramidate prodrug approach has been used with success in drug discovery. Herein, we describe the first application of this prodrug technology to the monophosphate derivative of the phosphoantigen HMBPP and one of its analogues. Some of these prodrugs exhibited specific and potent activation of V gamma 9/V delta 2 T-cells, which were then able to lyse bladder cancer cells in vitro. This work highlights the promise of this prodrug technology in the discovery of novel immunotherapeutics.
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