Journal
JOURNAL OF MEDICAL MICROBIOLOGY
Volume 67, Issue 8, Pages 1047-1049Publisher
MICROBIOLOGY SOC
DOI: 10.1099/jmm.0.000793
Keywords
CRE; colistin resistance; Mcr-1; NDM-5
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Funding
- Japan Society for the Promotion of Science [18K07120]
- Research Program on Emerging and Re-emerging Infectious Diseases of the Japan Agency for Medical Research and Development [18fk0108061]
- Grants-in-Aid for Scientific Research [18K07120] Funding Source: KAKEN
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The mcr-1 gene encodes a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. This study describes the emergence of a colistin- and carbapenem-resistant clinical isolate of Escherichia coli harbouring mcr-1 and bla(NDM-5) genes, located on 90 and 150 Kb plasmids, respectively. The isolate belonged to ST132. This is the first report of a clinical isolate in Japan co-harbouring mcr-1 and bla(NDM-5).
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