Journal
JOURNAL OF MEDICAL MICROBIOLOGY
Volume 67, Issue 8, Pages 1042-1046Publisher
MICROBIOLOGY SOC
DOI: 10.1099/jmm.0.000789
Keywords
molybdenum oxide; nanoparticles; multidrug-resistant bacteria; bactericidal efficacy
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Funding
- FEDER funds through COMPETE2020 - Programa Operacional Competitividade e Internacionalizacao (POCI) [UID/CTM/50025/2013]
- Fundacao para a Ciencia e a Tecnologia (FCT), Portugal
- FCT, Portugal [03/BI/2017]
- [LISBOA-01-0145-FEDER-007660]
- [PTDC/DTP-EPI/0842/2014]
- [PTDC/FIS/NAN/0117/2014]
- Fundação para a Ciência e a Tecnologia [PTDC/FIS-NAN/0117/2014] Funding Source: FCT
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Multidrug-resistant bacteria pose a major threat to effective antibiotics and alternatives to fight multidrug-resistant pathogens are needed. We synthetized molybdenum oxide (MoO3) nanoparticles (NP) and determined their antibacterial activity against 39 isolates: (i) eight Staphylococcus aureus, including representatives of methicillin-resistant S. aureus epidemic clones; (ii) six enterococci, including vancomycin-resistant isolates; and (iii) 25 Gram-negative isolates (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter cloacae), including extended spectrum beta-lactamases and carbapenemases producers. All isolates showed a MoO3 NP MIC of 700-800 mg l(-1). MoO3 NP produced a clear inhibition zone for S. aureus and all Gram-negative isolates at concentrations >= 25 mg ml(-1) and >= 50 mg ml(-1) for enterococci. When the NP solutions were adjusted to pH similar to 7, the biocidal activity was completely abolished. MoO3 NP create an acidic pH and show a universal antimicrobial activity against susceptible and resistant isolates belonging to the most relevant bacterial species responsible for hospital-acquired infections.
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