Journal
JOURNAL OF MATHEMATICAL BIOLOGY
Volume 76, Issue 7, Pages 1907-1950Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00285-018-1213-2
Keywords
Wolbachia-based biocontrol; wMelPop strain; Aedes aegypti; Sex-structured model; Optimal control; Optimal release policies
Categories
Funding
- COLCIENCIAS (Colombian Ministry of Science, Technology, and Innovation) [12595-6933846]
- COLCIENCIAS
- Universidad del Valle [CI-71089]
- STIC [16-STIC-02 MOSTICAW]
- Grants-in-Aid for Scientific Research [15K05900] Funding Source: KAKEN
Ask authors/readers for more resources
Wolbachia-based biocontrol has recently emerged as a potential method for prevention and control of dengue and other vector-borne diseases. Major vector species, such as Aedes aegypti females, when deliberately infected with Wolbachia become less capable of getting viral infections and transmitting the virus to human hosts. In this paper, we propose an explicit sex-structured population model that describes an interaction of uninfected (wild) male and female mosquitoes and those deliberately infected with wMelPop strain of Wolbachia in the same locality. This particular strain of Wolbachia is regarded as the best blocker of dengue and other arboviral infections. However, wMelPop strain of Wolbachia also causes the loss of individual fitness in Aedes aegypti mosquitoes. Our model allows for natural introduction of the decision (or control) variable, and we apply the optimal control approach to simulate wMelPop Wolbachia infestation of wild Aedes aegypti populations. The control action consists in continuous periodic releases of mosquitoes previously infected with wMelPop strain of Wolbachia in laboratory conditions. The ultimate purpose of control is to find a tradeoff between reaching the population replacement in minimum time and with minimum cost of the control effort. This approach also allows us to estimate the number of Wolbachia-carrying mosquitoes to be released in day-by-day control action. The proposed method of biological control is safe to human health, does not contaminate the environment, does not make harm to non-target species, and preserves their interaction with mosquitoes in the ecosystem.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available