Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 32, Issue 17, Pages 2950-2952Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14767058.2018.1450864
Keywords
Human milk oligosaccharides; anti-adhesive effect; 2 '-fucosyllactose; 6 '-sialyllactose
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Funding
- Mancini Foundation
- Fabriano, Italy
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Background: It is well known that human milk oligosaccharides play an important role as prebiotics, anti-inflammatory, and anti-infective agents. In the last few years, several studies have been performed using specific oligosaccharides, such as 2-fucosyllactose and 6-sialylactose, to evaluate their biological functions.Objectives: The aim of the present study is to evaluate the anti-adhesive effect of the above oligosaccharides on Escherichia coli and Salmonella fyris.Methods: Adhesion experiments were performed in the presence of 2 '-fucosyllactose and 6 '-sialyllactose as potential inhibitors of Escherichia coli and Salmonella fyris adhesion to Caco-2 cells. The oligosaccharides were used at different concentrations and the adhesion experiments were performed in triplicate and repeated at least three times.Results: A significant reduction of Escherichia coli adhesion was observed in the presence of 2 '-fucosyllactose and 6 '-sialyllactose at the human milk concentration. On the contrary, no positive effects were observed in both oligosaccharides on Salmonella firis.Conclusions: Our results suggest that the supplementation in infant formulas of 2 '-fucosyllactose and 6 '-sialyllactose, actually commercially available and absent in cow milk, could play positive effects in artificially fed infants.
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