Journal
JOURNAL OF MATERIALS RESEARCH
Volume 33, Issue 14, Pages 1972-1986Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1557/jmr.2018.111
Keywords
3D printing; composite ink; bone tissue regeneration; calvarial defects
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Funding
- National Science Foundation [1600118]
- Osteology Foundation [15-042]
- International Postdoctoral Research Scholarship Program of the Scientific and Technological Research Council of Turkey (TUBITAK) [BIDEP 2219]
- Directorate For Engineering [1600118] Funding Source: National Science Foundation
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Three-dimensional (3D) printing technology is a promising method for bone tissue engineering applications. For enhanced bone regeneration, it is important to have printable ink materials with appealing properties such as construct interconnectivity, mechanical strength, controlled degradation rates, and the presence of bioactive materials. In this respect, we develop a composite ink composed of polycaprolactone (PCL), poly(D,L-lactide-co-glycolide) (PLGA), and hydroxyapatite particles (HAps) and 3D print it into porous constructs. In vitro study revealed that composite constructs had higher mechanical properties, surface roughness, quicker degradation profile, and cellular behaviors compared to PCL counterparts. Furthermore, in vivo results showed that 3D-printed composite constructs had a positive influence on bone regeneration due to the presence of newly formed mineralized bone tissue and blood vessel formation. Therefore, 3D printable ink made of PCL/PLGA/HAp can be a highly useful material for 3D printing of bone tissue constructs.
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