Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 456, Issue -, Pages 316-323Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2018.02.053
Keywords
Poly (epsilon-caprolactone); Fe3O4; Doxorubicin hydrochloride; Composite microspheres; Magnetic resonance imaging; Drug delivery
Funding
- Natural Science Foundation of Hebei Province [H2016402026]
- Science and Technology Research Development Program of Handan [1721211051-2]
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In this study, poly (epsilon-caprolactone) (PCL) microspheres loading magnetic Fe3O4 nanoparticles and anticancer drug of doxorubicin hydrochloride (DOX) were successfully prepared by a modified solvent-evaporation method. The obtained magnetic composite microspheres exhibited dual features of magnetic resonance imaging and controlled drug delivery. The morphology, structure, thermal behavior and magnetic properties of the drug-loaded magnetic microspheres were investigated in detail by SEM, XRD, DSC and SQUID. The obtained composite microspheres showed superparamagnetic behavior and T-2-weighted enhancement effect. The drug loading, encapsulation efficiency, releasing behavior and in vitro cytotoxicity of the drug-loaded composite microspheres were systematically investigated. It was found that the values of drug loading and encapsulation efficiency were 36.7% and 25.8%, respectively. The composite microspheres were sensitive to pH and released in a sustained way, and both the release curves under various pH conditions (4.0 and 7.4) were well satisfied with the biphase kinetics function. In addition, the magnetic response of the drug-loaded microspheres was studied and the results showed that the composite microspheres had a good magnetic stability and strong targeting ability. (C) 2018 Elsevier B.V. All rights reserved.
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