Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 453, Issue -, Pages 132-136Publisher
ELSEVIER
DOI: 10.1016/j.jmmm.2018.01.010
Keywords
Magnetic particle labels; Biodetection; GMR sensor; Limitation of detection
Funding
- National Natural Science Foundation of China [11604172, 11674187, 11504192, 11704211]
Ask authors/readers for more resources
In the broad research of the GMR bio-sensing technology, it is vital to explore appropriate magnetic labels and its influences on the detection signal. In this work, four kinds of ferrite particles of gamma-Fe2O3, CoFe2O4, NiFe2O4 and NiZnFe2O4 were prepared through calcining the Dimethyl Formamide (DMF) solution of the transition metal nitrates [Fe(NO3)(3) and X(NO3)(2), X = Co, Ni, Zn] to study the effect of magnetic properties on detection signals using a DC in-plane measuring method. It was revealed that for four particles, the output voltage differences vertical bar Delta V vertical bar between with and without magnetic particles exhibit log-linear functions of the particles concentrations x in the range from 0.1 to 10 ng/mL. A very low limitation of detection (LOD) of 0.1 ng/mL for all the samples was obtained, which is two orders smaller than that in the previous work. Moreover, the change of output voltage difference at the LOD (vertical bar Delta V-lim vertical bar) is proportional to the magnetization at bias field (bias magnetization, M-bias), which indicates that larger M-bias leads to a lower LOD. This work provides a useful guidance in selecting or preparing magnetic labels to enhance the sensitivity of GMR biosensors. (C) 2018 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available