Journal
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
Volume 79, Issue 1-2, Pages 65-73Publisher
SPRINGER
DOI: 10.1007/s10847-013-0324-z
Keywords
Dendrimers; PAMAM; Triazine N-oxide; Host-guest association; Antitumor drug stability
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Funding
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET-Argentina)
- Agencia Nacional de Promocion Cientifica y Tecnologica (FONCYT-Argentina)
- Secretaria de Ciencia y Tecnica de la Universidad Nacional de Rio Cuarto (SECYT-UNRC)
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The interaction between a 1,2,4-triazine N-oxide derivative, that holds potential antitumor activity under hypoxic conditions, and diverse polyamidoamine (PAMAM) dendrimers were investigated with the purpose of select the most appropriate macromolecule to act as potential molecular carrier of this active compound. The results shows that dendrimers with amine terminal groups (PAMAM-AT G = 3) and dendrimers with carboxylate terminal groups (PAMAM-CT G2.5 and G4.5) produces triazine derivative hydrolysis, even in buffered medium, and are not suitable as carriers. In contrast, dendrimers with neutral end groups (PAMAM-OHT) shows stable association with the active compound, making this dendrimer a possible medium for triazine carriage.
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