Journal
EMBO REPORTS
Volume 15, Issue 6, Pages 705-713Publisher
WILEY-BLACKWELL
DOI: 10.1002/embr.201338310
Keywords
autophagy; Caenorhabditis elegans; ER stress; mitochondrial stress; Rb
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Funding
- National Basic Research Program of China [2013CB910100, 2011CB910100]
- NSFC [31225018]
- International Early Career Scientist Grant from the Howard Hughes Medical Institute
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The mechanisms that coordinate the regulation of autophagy with developmental signaling during multicellular organism development remain largely unknown. Here, we show that impaired function of ribosomal protein RPL-43 causes an accumulation of SQST-1 aggregates in the larval intestine, which are removed upon autophagy induction. Using this model to screen for autophagy regulators, we identify 139 genes that promote autophagy activity upon inactivation. Various signaling pathways, including Sma/Mab TGF-beta signaling, lin-35/Rb signaling, the XBP-1-mediated ER stress response, and the ATFS-1-mediated mitochondrial stress response, regulate the expression of autophagy genes independently of the TFEB homolog HLH-30. Our study thus provides a framework for understanding the role of signaling pathways in regulating autophagy under physiological conditions.
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