Related references
Note: Only part of the references are listed.P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease
Francisco Saez-Orellana et al.
NEUROPHARMACOLOGY (2018)
The Simple Western™: a gel-free, blot-free, hands-free Western blotting reinvention
Uyen Nguyen et al.
NATURE METHODS (2018)
Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120
Rebecca C. Allsopp et al.
SCIENTIFIC REPORTS (2017)
ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies
Anat Boehm-Cagan et al.
JOURNAL OF ALZHEIMERS DISEASE (2016)
Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes
Jianjia Fan et al.
PLOS ONE (2016)
ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease
Hussein N. Yassine et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)
Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease
Liv Tybjaerg Nordestgaard et al.
ALZHEIMERS & DEMENTIA (2015)
microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain
Jaekwang Kim et al.
JOURNAL OF NEUROSCIENCE (2015)
Liver X receptors in lipid metabolism: opportunities for drug discovery
Cynthia Hong et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
ATP-binding cassette transporter A1: From metabolism to neurodegeneration
Radosveta Koldamova et al.
NEUROBIOLOGY OF DISEASE (2014)
The Liver X Receptor Agonist T0901317 Protects Mice from High Fat Diet-Induced Obesity and Insulin Resistance
Mingming Gao et al.
AAPS JOURNAL (2013)
Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease
Andrew B Wolf et al.
Alzheimers Research & Therapy (2013)
Evidence for impaired amyloid beta clearance in Alzheimer's disease
Kristin R. Wildsmith et al.
ALZHEIMERS RESEARCH & THERAPY (2013)
Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine
Edward C. Keystone et al.
ANNALS OF THE RHEUMATIC DISEASES (2012)
Modulation of RXR function through ligand design
Efren Perez et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)
In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases
Juan Ignacio Diaz-Hernandez et al.
NEUROBIOLOGY OF AGING (2012)
Molecular and functional properties of P2X receptors-recent progress and persisting challenges
Karina Kaczmarek-Hajek et al.
PURINERGIC SIGNALLING (2012)
Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
David M. Holtzman et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Two Panels of Steroid Receptor Luciferase Reporter Cell Lines for Compound Profiling
David Sedlak et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2011)
Microglial P2X7 receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease
Hwan Goo Lee et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2011)
An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia
Jianjia Fan et al.
JOURNAL OF LIPID RESEARCH (2011)
The P2X7 purinergic receptor: from physiology to neurological disorders
Stephen D. Skaper et al.
FASEB JOURNAL (2010)
ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice
James J. Donkin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Discovery of Tertiary Sulfonamides as Potent Liver X Receptor Antagonists
William J. Zuercher et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Liver X receptor agonists with selectivity for LXRβ; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides
Britt-Marie Swahn et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
A Survey of ABCA1 Sequence Variation Confirms Association with Dementia
Chandra A. Reynolds et al.
HUMAN MUTATION (2009)
Antagonists of the P2X7 Receptor. From Lead Identification to Drug Development
Simon D. Guile et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Negative Regulation of Hedgehog Signaling by Liver X Receptors
Woo-Kyun Kim et al.
MOLECULAR ENDOCRINOLOGY (2009)
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
Suzanne E. Wahrle et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
ApoE promotes the proteolytic degradation of Aβ
Qingguang Jiang et al.
NEURON (2008)
Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimer's disease
Jae K. Ryu et al.
NEUROREPORT (2008)
Good statistical practice in pharmacology - Problem 2
M. Lew
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Discovery of potent and selective adamantane-based small-molecule P2X7 receptor antagonists/interleukin-1β,6 inhibitors
Mark Furber et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Characterization of a selective and potent antagonist of human P2X7 receptors, AZ11645373
L. Stokes et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
Isoelectric focusing technology quantifies protein signaling in 25 cells
Roger A. O'Neill et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
V Hirsch-Reinshagen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice
R Koldamova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Deletion of Abca1 increases Aβ deposition in the PDAPP transgenic mouse model of Alzheimer disease
SE Wahrle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain
V Hirsch-Reinshagen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse
JW Chisholm et al.
JOURNAL OF LIPID RESEARCH (2003)
Share Paper
