Journal
GLIA
Volume 63, Issue 8, Pages 1394-1405Publisher
WILEY
DOI: 10.1002/glia.22858
Keywords
microglia; subventricular zone; subgranular zone; neurogenesis; cytokine
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Funding
- Program for Promotion of Fundamental Studies in Health Sciences of NIBIO, Japan
- grant for Research on Risks of Chemicals, Health and Labour Sciences Research Grants on Research on Regulatory Science of Pharmaceuticals and Medical Devices
- Labor Science Research Grant for Research on New Drug Development from the MHLW, Japan
- Japan Agency for Medical Research and development (AMED)
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This review summarizes and organizes the literature concerning the effects of microglia on neurogenesis, particularly focusing on the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) of the lateral ventricles, in which the neurogenic potential is progressively restricted during the life of the organism. A comparison of microglial roles in neurogenesis in these two regions indicates that microglia regulate neurogenesis in a temporally and spatially specific manner. Microglia may also sense signals from the surrounding environment and have regulatory effects on neurogenesis. We speculate microglia function as a hub for the information obtained from the inner and outer brain regions for regulating neurogenesis. GLIA 2015;63:1394-1405
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