Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 103, Issue 6, Pages 1205-1217Publisher
WILEY
DOI: 10.1002/JLB.3MIR1117-459R
Keywords
exosomes; extracellular vesicles; inflammation; innate immunity; macrophage; miRNAs; monocyte; NF-B
Categories
Ask authors/readers for more resources
MicroRNAs (miRNAs) are small noncoding RNA and are pivotal posttranscriptional regulators of both innate and adaptive immunity. They act by regulating the expression of multiple immune genes, thus, are the important elements to the complex immune regulatory network. Deregulated expression of specific miRNAs can lead to potential autoimmunity, immune tolerance, hyper-inflammatory phenotype, and cancer initiation and progression. In this review, we discuss the contributory pathways and mechanisms by which several miRNAs influence the development of innate immunity and fine-tune immune response. Moreover, we discuss the consequence of deregulated miRNAs and their pathogenic implications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available