Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 103, Issue 6, Pages 1219-1223Publisher
WILEY
DOI: 10.1002/JLB.5MIR0917-351R
Keywords
IFN-gamma; immunotherapy; tumor dormancy; tumor immunoediting
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Funding
- Office of the Assistant Secretary of Defense for Health Affairs through the Breast Cancer Research Program [W81XWH-14-1-0087]
- VCU Massey Cancer Center
- NIH/NCI Cancer Center Support Grant [P30 CA016059]
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Tumor immunoediting consisting of three phases of elimination, equilibrium or dormancy, and escape has been supported by preclinical and clinical data. A comprehensive understanding of the molecular mechanisms by which antitumor immune responses regulate these three phases are important for developing highly tailored immunotherapeutics that can control cancer. To this end, IFN- produced by Th1 cells, cytotoxic T cells, NK cells, and NKT cells is a pleiotropic cytokine that is involved in all three phases of tumor immunoediting, as well as during inflammation-mediated tumorigenesis processes. This essay presents a review of literature and suggests that overcoming tumor escape is feasible by driving tumor cells into a state of quiescent but not indolent dormancy in order for IFN--producing tumor-specific T cells to prevent tumor relapse.
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