Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 103, Issue 6, Pages 1099-1116Publisher
WILEY
DOI: 10.1002/JLB.2MIR0817-342R
Keywords
negative regulation; type I interferon
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Funding
- [R01CA177305]
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Type I IFNs (,, and others) are a family of cytokines that are produced in physiological conditions as well as in response to the activation of pattern recognition receptors.They are critically important in controlling the host innate and adaptive immune response to viral and some bacterial infections, cancer, and other inflammatory stimuli. However, dysregulation of type I IFN production or response can contribute to immune pathologies termed interferonopathies, pointing to the importance of balanced activating signals with tightly regulated mechanisms of tuning this signaling. Here, we summarize the recent advances of how type I IFN production and response are controlled at multiple levels of the type I IFN signaling cascade.
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