Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 104, Issue 4, Pages 691-699Publisher
WILEY
DOI: 10.1002/JLB.1RI0418-160R
Keywords
chromatin accessibility; DNA methylation; histone modification; immunosenescence; Tcell differentiation; transcription factor
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Funding
- National Institutes of Health [R01 AR042527, R01 HL117913, R01 AI108906, P01 HL129941, R01 AI108891, R01 AG045779, U19 AI057266, R01 AI129191, I01 BX001669]
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T cells are a heterogeneous population of cells that differ in their differentiation stages. Functional states are reflected in the epigenome that confers stability in cellular identity and is therefore important for naive as well as memory Tcell function. In many cellular systems, changes in chromatin structure due to alterations in histone expression, histone modifications and DNA methylation are characteristic of the aging process and cause or at least contribute to cellular dysfunction in senescence. Here, we review the epigenetic changes in Tcells that occur with age and discuss them in the context of canonical epigenetic marks in aging model systems as well as recent findings of chromatin accessibility changes in Tcell differentiation. Remarkably, transcription factor networks driving Tcell differentiation account for many of the age-associated modifications in chromatin structures suggesting that loss of quiescence and activation of differentiation pathways are major components of Tcell aging.
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