Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 104, Issue 4, Pages 737-741Publisher
WILEY
DOI: 10.1002/JLB.3MR0118-034R
Keywords
alveolar macrophages; asthma; PPAR-gamma; Th2
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Funding
- Swiss National Science Foundation (SNSF) Early Postdoctoral Fellowship
- Swiss National Science Foundation [310030_163443/1]
- ETH [34-13-1]
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The transcription factor PPAR-gamma (peroxisome proliferator-activated receptor-gamma) is a key regulator of lung immunity exhibiting multiple cell type specific roles in controlling development and function of the lung immune system. It is strictly required for the generation of alveolar macrophages by controlling differentiation of fetal lung monocyte precursors. Furthermore, it plays an important role in lung allergic inflammation by licensing lung dendritic cell t helper 2 (Th2) priming capacity as well as acting as a master transcription factor for pathogenic Th2 cells. Due to this plethora of functions and its involvement in multiple pulmonary diseases including asthma and pulmonary alveolar proteinosis, understanding the role of PPAR-gamma in lung immunity is an important subject of ongoing research.
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