Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 104, Issue 2, Pages 323-331Publisher
WILEY
DOI: 10.1002/JLB.2MR1217-503R
Keywords
cell signaling; chemokine receptors; imaging-based approaches; receptor conformations
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Funding
- Secretaria de Estado de Investigacion, Desarrollo e Innovacion [SAF 2014-53416-R, SAF 2017-82940-R]
- RETICS program of the Instituto de Salud Carlos III [RD16/0012/0006]
- COMFUTURO program from the Fundacion General CSIC
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The chemokines direct leukocyte recruitment in both homeostatic and inflammatory conditions, and are therefore critical for immune reactions. By binding to members of the class A G protein-coupled receptors, the chemokines play an essential role in numerous physiological and pathological processes. In the last quarter century, the field has accumulated much information regarding the implications of these molecules in different immune processes, as well as mechanistic insight into the signaling events activated through their binding to their receptors. Here, we will focus on chemokine receptors and how new methodological approaches have underscored the role of their conformations in chemokine functions. Advances in biophysical-based techniques show that chemokines and their receptors act in very complex networks and therefore should not be considered isolated entities. In this regard, the chemokine receptors can form homo - and heterodimers as well as oligomers at the cell surface. These findings are changing our view as to how chemokines influence cell biology, identify partners that regulate chemokine function, and open new avenues for therapeutic intervention.
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