Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 138, Issue 2, Pages 355-364Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2017.08.038
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- ATIP-AVENIR grant
- ANR JCJC grant
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Vitiligo is a chronic autoimmune depigmenting skin disorder that results from a loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with a prominent role of the immune system, in particular T cells. After repigmentation, vitiligo frequently recurs in the same area, suggesting that vitiligo could involve the presence of resident memory T cells (T-RM). We sought to perform a thorough characterization of the phenotype and function of skin memory T cells in vitiligo. We show that stable and active vitiligo perilesional skin is enriched with a population of CD8 T-RM expressing both CD69 and CD103 compared with psoriasis and control unaffected skin. CD8 T-RM expressing CD103 are mainly localized in the epidermis. Expression of CXCR3 is observed on most CD8 T-RM in vitiligo, including the population of melanocyte-specific CD8 T cells. CD8 T-RM displayed increased production of IFN-gamma and tumor necrosis factor-alpha with moderate cytotoxic activity. Our study highlights the presence of functional CD8 T-RM in both stable and active vitiligo, reinforcing the concept of vitiligo as an immune memory skin disease. The CD8 T-RM that remain in stable disease could play a role during disease flares, emphasizing the interest in targeting this cell subset in vitiligo.
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