Journal
BEHAVIORAL SCIENCES
Volume 4, Issue 2, Pages 125-153Publisher
MDPI
DOI: 10.3390/bs4020125
Keywords
neurotensin; schizophrenia; antipsychotic drugs; addiction; autism spectrum disorder; animal models
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Funding
- Mayo Foundation for Medical Education and Research
- National Institutes of Health (NIH)
- National Center for Research Resources (NCRR) CTSA [UL1 TR000064, KL2TR000065]
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Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders. This review outlines data implicating NT in the pathophysiology and management of major mental disorders such as schizophrenia, drug addiction, and autism. The data suggest that NT receptor analogs have the potential to be used as novel therapeutic agents acting through modulation of neurotransmitter systems dys-regulated in these disorders.
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