Journal
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume 46, Issue 3, Pages 1197-1208Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0300060517737211
Keywords
Mean platelet volume; platelet distribution width; mortality; children; mechanical ventilation
Funding
- the Zhejiang Medical and Health Science and Technology Plan Project [2007 B119]
- Zhejiang Medical and Health Science and Technology Plan Project [2012 KYB119]
- Natural Science Foundation of Zhejiang Province [LY12 H19006]
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Objectives To investigate platelet volume indices and in-hospital mortality in children on mechanical ventilation. Methods This retrospective study included children aged <16 years on mechanical ventilation, and compared parameters, measured on admission, between survivors and non-survivors. Dynamic platelet volume indices over the first 7 days were visualized. Independent risk factors of mortality were identified using multivariate logistic regression analysis. Results Out of 2319 children aged 28 days-3 years, serum albumin (odds ratio [OR] 0.9, 95% confidence interval [CI] 0.85, 0.96), bilirubin (OR 1.01, 95% CI 1.0, 1.77), and lactic acid (OR 1.22, 95% CI 1.05, 1.38) levels were associated with mortality. Out of 2415 children aged>3 years, procalcitonin (OR 1.01, 95% CI 1.0, 1.01) and lactic acid (OR 1.22, 95% CI 1.09, 1.35) were associated with mortality. Platelet volume indices on admission were not independently associated with mortality in either group. Mean platelet volume (MPV) and platelet distribution width (PDW) showed different trends in non-survivors versus survivors over 1 week in both age groups. Conclusions Platelet volume indices may be associated with mortality in critically ill children receiving mechanical ventilation.
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