Journal
JOURNAL OF INNATE IMMUNITY
Volume 10, Issue 5-6, Pages 432-441Publisher
KARGER
DOI: 10.1159/000487756
Keywords
Bacterial pathogenesis; Virulence; Phagocytosis; Neutrophil; Host defense; Innate immunity
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Funding
- Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000900] Funding Source: NIH RePORTER
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Neutrophils are an important component of the innate immune system and provide a front line of defense against bacterial infection. Although most bacteria are killed readily by neutrophils, some bacterial pathogens have the capacity to circumvent destruction by these host leukocytes. The ability of bacterial pathogens to avoid killing by neutrophils often involves multiple attributes or characteristics, including the production of virulence molecules. These molecules are diverse in composition and function, and collectively have the potential to alter or inhibit neutrophil recruitment, phagocytosis, bactericidal activity, and/or apoptosis. Here, we review the ability of bacteria to target these processes. (c) 2018 S. Karger AG, Basel
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