4.7 Article

Secondary Bacterial Pneumonia by Staphylococcus aureus Following Influenza A Infection Is SaeR/S Dependent

Journal

JOURNAL OF INFECTIOUS DISEASES
Volume 218, Issue 5, Pages 809-813

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiy210

Keywords

Staphylococcus aureus; SaeR/S; influenza A; coinfection; superinfection; pneumonia

Funding

  1. US National Institutes of Health [R01A1090046, R01AI103353, GM110732, U54GM115371]
  2. Montana University System Research Initiative [51040-MUSRI2015-03]
  3. Montana State University Agriculture Experiment Station
  4. Murdock Charitable Trust
  5. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI103353] Funding Source: NIH RePORTER
  6. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [U54GM115371] Funding Source: NIH RePORTER

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Staphylococcus aureus is a predominant cause of fatal pneumonia following influenza A virus (IAV) infection. Herein we investigate the influence of antecedent IAV infection on S. aureus virulence gene expression. Using a murine model, comparing the USA300 and USA300.saeR/S strains, we demonstrate that S. aureus pathogenesis following IAV infection is SaeR/S dependent. Furthermore, we show that IAV modulates the lung environment to rapidly up-regulate S. aureus virulence factors containing the SaeR-binding domain. Data demonstrate that the pathogen response to IAV infection impacts host outcome and provides evidence that the ability of S. aureus to sense and respond to the lung environment determines severity of pneumonia.

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