Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 218, Issue 6, Pages 1009-1013Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiy259
Keywords
Staphylococcus aureus; agr quorum sensing inhibition; atopic dermatitis; delta-toxin; antivirulence therapy
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Funding
- European Union [289285]
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Atopic dermatitis (AD) is a chronic inflammatory skin disease where more than 90% of patients affected are colonized with Staphylococcus aureus. In AD, S. aureus delta-toxin is a major virulence factor causing cutaneous inflammation via mast cell degranulation. d-toxin is controlled by the S. aureus agr quorum sensing system, and thus we addressed whether interference with agr signaling would limit skin inflammation. Indeed, treatment of S. aureus with the agr-inhibitor solonamide B (SolB) abolished d-toxin production and reduced skin inflammation in a mouse model of inflammatory skin disease, demonstrating the potential of antivirulence therapy in treating S. aureus-induced skin disorders.
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