Journal
JOURNAL OF INFECTION
Volume 77, Issue 2, Pages 83-98Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2018.04.007
Keywords
SELEX; Aptamer; Infectious disease; Diagnosis; Therapy
Categories
Funding
- National Grand Program on Key Infectious Disease [2017ZX10201301-006]
- National Natural Science Foundation of China [81471910, 31770145, 31370197, 21572173, 81501377, 91740120]
- National Outstanding Youth Foundation of China [81025008]
- Major Projects of Technological Innovation of Hubei Province [2016ACA150, 2016CFA062]
- Science and Technology Program of Wuhan [201150530141]
- Wuhan Youth Science and Technology Chen'guang Plan [2016070204010127]
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The entire human population is at risk of infectious diseases worldwide. Thus far, the diagnosis and treatment of human infectious diseases at the molecular and nanoscale levels have been extremely challenging tasks because of the lack of effective probes to identify and recognize biomarkers of pathogens. Oligonucleotide aptamers are a class of small nucleic acid ligands that are composed of single-stranded DNA (ssDNA) or RNA and act as affinity probes or molecular recognition elements for a variety of targets. These aptamers have an exciting potential for diagnose and/or treatment of specific diseases. In this review, we highlight areas where aptamers have been developed as diagnostic and therapeutic agents for both bacterial and viral infectious diseases as well as aptamer-based detection. (C) 2018 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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